• Corpus ID: 86106785

Immunopathologic Studies of Systemic Lupus Erythema- tosus (SLE). I. Tissue-bound Immunoglobulins in Relation to Serum Antinuclear Immuno-

@inproceedings{Svec1967ImmunopathologicSO,
  title={Immunopathologic Studies of Systemic Lupus Erythema- tosus (SLE). I. Tissue-bound Immunoglobulins in Relation to Serum Antinuclear Immuno-},
  author={K. H. Svec and J. Blair and M. H. Kaplan},
  year={1967}
}
Summary. We studied the composition of tissue-bound immunoglobulins and of antinuclear factors by immunofluorescent techniques in five patients with systemic lupus and two with chronic liver disease associated with positive LE cell tests. Renal glomeruli in all seven demonstrated deposits of bound yG-globulin and complement, although the presence of -yA- and yMimmunoglobulins was variable. Blood vessel walls contained primarily yGglobulin and complement in the systemic lupus patients, but such… 
Immunological Mechanisms in the Pathogenesis of Systemic Lupus Erythematosus
TLDR
Some of the important advances in the immunopathology of S.L.E. has implications not only for the physician who has to diagnose and manage patients with the disease, but also for the laboratory investigator studying the pathogenesis of diseases of disturbed immunity.

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