Immunopathogenesis of SLE.

  title={Immunopathogenesis of SLE.},
  author={Lesley J. Mason and David Isenberg},
  journal={Bailliere's clinical rheumatology},
  volume={12 3},
Systemic lupus erythematosus (SLE) is an autoimmune rheumatic disease characterized by the deposition of autoantibodies and immune complexes, leading to tissue damage. The immunopathogenesis of SLE is like a jigsaw puzzle, some pieces of which are missing or have not fallen into place. In predisposed individuals, the initial stimulus is likely to be one or more of the environmental agents interacting with susceptibility genes. Once the critical threshold is breached there is a failure of the… CONTINUE READING