Immunopathogenesis of Oropharyngeal Candidiasis in Human Immunodeficiency Virus Infection

@article{deRepentigny2004ImmunopathogenesisOO,
  title={Immunopathogenesis of Oropharyngeal Candidiasis in Human Immunodeficiency Virus Infection},
  author={Louis de Repentigny and Daniel Lewandowski and Paul Jolicoeur},
  journal={Clinical Microbiology Reviews},
  year={2004},
  volume={17},
  pages={729 - 759}
}
SUMMARY Oropharyngeal and esophageal candidiases remain significant causes of morbidity in human immunodeficiency virus (HIV)-infected patients, despite the dramatic ability of antiretroviral therapy to reconstitute immunity. Notable advances have been achieved in understanding, at the molecular level, the relationships between the progression of HIV infection, the acquisition, maintenance, and clonality of oral candidal populations, and the emergence of antifungal resistance. However, the… Expand
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TLDR
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TLDR
Results indicate that defective CD4+ T cells primarily determine the susceptibility to chronic carriage of C. albicans in these Tg mice. Expand
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TLDR
IL-17-mediated protective immune response is essential for oral mucosal immunity to C. albicans infection, and these responses induce regulatory immune responses that maintain tissue tolerance to the commensal fungi. Expand
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