Immunopathogenesis of Graves' ophthalmopathy: the role of the TSH receptor.

  title={Immunopathogenesis of Graves' ophthalmopathy: the role of the TSH receptor.},
  author={Seethalakshmi R Iyer and Rebecca S. Bahn},
  journal={Best practice & research. Clinical endocrinology & metabolism},
  volume={26 3},
Graves' ophthalmopathy is an inflammatory autoimmune disorder of the orbit. The close clinical and temporal relationships between Graves' hyperthyroidism and ophthalmopathy have long suggested that both conditions derive from a single systemic process and share the thyrotropin receptor as a common autoantigen. This receptor is expressed not only in thyroid follicular cells, but also in orbital fibroblasts with higher levels measured in orbital cells from ophthalmopathy patients than in cells… CONTINUE READING
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