Immunopathogenesis of Graves' ophthalmopathy: the role of the TSH receptor.

@article{Iyer2012ImmunopathogenesisOG,
  title={Immunopathogenesis of Graves' ophthalmopathy: the role of the TSH receptor.},
  author={Seethalakshmi R Iyer and Rebecca S. Bahn},
  journal={Best practice & research. Clinical endocrinology & metabolism},
  year={2012},
  volume={26 3},
  pages={281-9}
}
Graves' ophthalmopathy is an inflammatory autoimmune disorder of the orbit. The close clinical and temporal relationships between Graves' hyperthyroidism and ophthalmopathy have long suggested that both conditions derive from a single systemic process and share the thyrotropin receptor as a common autoantigen. This receptor is expressed not only in thyroid follicular cells, but also in orbital fibroblasts with higher levels measured in orbital cells from ophthalmopathy patients than in cells… CONTINUE READING
24 Citations
70 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 24 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 70 references

IGF-1 receptor blockade inhibits hyaluronan synthesis induced by a stimulatory thyrotropin receptor antibody in Graves’ orbital fibroblasts

  • S Kumar, S Iyer, H Bauer
  • Thyroid
  • 2011

Detection of autoantibodies against the insulin-like growth factor-1 receptor in patients with Graves’ orbitopathy by luminescent immunoprecipitation analysis

  • W Minish, A Eckstein, N Dehina
  • Proc International thyroid Congress,
  • 2010

Similar Papers

Loading similar papers…