Immunopathogenesis and risk factors for allopurinol severe cutaneous adverse reactions

  title={Immunopathogenesis and risk factors for allopurinol severe cutaneous adverse reactions},
  author={C. Wang and Ro-Lan Dao and Wen-Hung Chung},
  journal={Current Opinion in Allergy and Clinical Immunology},
  • C. Wang, Ro-Lan Dao, Wen-Hung Chung
  • Published 2016
  • Medicine
  • Current Opinion in Allergy and Clinical Immunology
  • Purpose of reviewThe article reviews the immunopathogenesis and risk factors related to allopurinol-induced severe cutaneous adverse reactions (SCARs). Recent findingsFor years, allopurinol remains one of the leading cause for SCARs worldwide. The pathogenesis of allopurinol-induced SCARs have been discovered in recent years. HLA-B*58 : 01 has been found to be strongly associated with allopurinol-SCARs with functional interactions between allopurinol/its metabolite-oxypurinol and the T-cell… CONTINUE READING
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