Immunomorphological sequelae of severe brain injury induced by fluid-percussion in juvenile pigs – effects of mild hypothermia

@article{Brodhun2001ImmunomorphologicalSO,
  title={Immunomorphological sequelae of severe brain injury induced by fluid-percussion in juvenile pigs – effects of mild hypothermia},
  author={Michael Brodhun and Harald Fritz and Bernd Walter and Iwa Antonow-Schlorke and Konrad Reinhart and Ulrich Zwiener and Reinhard Bauer and Stephan Patt},
  journal={Acta Neuropathologica},
  year={2001},
  volume={101},
  pages={424-434}
}
Severe traumatic brain injury (TBI) often leads to a bad outcome with considerable neurological deficits. Secondary brain injuries due to a rise of intracranial pressure (ICP) and global hypoxia-ischemia are critical and may be reduced in extent by mild hypothermia. A porcine animal model was used to study the effect of severe TBI, induced by fluid percussion (FP; 3.5±0.3 atm) in combination with a secondary insult, i.e., temporary blood loss with hypovolemic hypotension. Six-week-old juvenile… CONTINUE READING