Immunomorphological characterization and effects of 12-(S)-HETE on a dynamic intracellular pool of the alpha IIb beta 3-integrin in melanoma cells.

@article{Tmr1995ImmunomorphologicalCA,
  title={Immunomorphological characterization and effects of 12-(S)-HETE on a dynamic intracellular pool of the alpha IIb beta 3-integrin in melanoma cells.},
  author={J{\'o}zsef T{\'i}m{\'a}r and Rajesh Bazaz and Victoria A. Kimler and Maher M Haddad and Dean G Tang and David P. Robertson and J{\'o}zsef T{\'o}v{\'a}ri and John Eric Taylor and Kenneth V. Honn},
  journal={Journal of cell science},
  year={1995},
  volume={108 ( Pt 6)},
  pages={2175-86}
}
In metastatic B16a murine melanoma cells, alpha IIb beta 3 integrin was shown to be one of the key adhesion molecules responsible for matrix adhesion and spreading. Upon stimulation, alpha IIb beta 3 can be upregulated at the cell surface due to translocation of the receptor to the plasma membrane from an intracellular pool. Here we have characterized this integrin pool as a tubulovesicular structure (TVS) corresponding to endosomes. TVS was found to be associated temporarily with microtubules… CONTINUE READING

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