Immunomodulatory responses of peripheral blood mononuclear cells from multiple sclerosis patients upon in vitro incubation with the flavonoid luteolin: additive effects of IFN-β

@article{Sternberg2009ImmunomodulatoryRO,
  title={Immunomodulatory responses of peripheral blood mononuclear cells from multiple sclerosis patients upon in vitro incubation with the flavonoid luteolin: additive effects of IFN-β},
  author={Zohara Z Sternberg and Kailash C. Chadha and Alicia Lieberman and Allison S. Drake and D Hojnacki and Bianca Weinstock-Guttman and Frederick E. Munschauer},
  journal={Journal of Neuroinflammation},
  year={2009},
  volume={6},
  pages={28 - 28}
}
The study is aimed to determine the role of luteolin (3',4',5,7-tetrahydroxyflavone), alone and in combination with human interferon-beta (IFN-β), in modulating the immune response(s) of peripheral blood mononuclear cells (PBMCs) isolated from multiple sclerosis (MS) patients. PBMC proliferation in the presence or absence of these drugs was determined and the production of pro-inflammatory cytokines (IL-1β, TNF-α), and the ratio of cell migration mediator MMP-9, and its inhibitor, TIMP-1 was… CONTINUE READING