Immunomodulatory pretreatment with Kalanchoe pinnata extract and its quercitrin flavonoid effectively protects mice against fatal anaphylactic shock.

@article{Cruz2008ImmunomodulatoryPW,
  title={Immunomodulatory pretreatment with Kalanchoe pinnata extract and its quercitrin flavonoid effectively protects mice against fatal anaphylactic shock.},
  author={E. A. Sandoval Cruz and S{\'i}lvia Amaral Gonçalves Da-Silva and Michelle Fraz{\~a}o Muzitano and Patr{\'i}cia Machado Rodrigues e Silva and S{\^o}nia Soares Costa and Bartira Rossi-Bergmann},
  journal={International immunopharmacology},
  year={2008},
  volume={8 12},
  pages={
          1616-21
        }
}
Previously, we reported the immunosuppressive action of the aqueous extract of Kalanchoe pinnata (Kp) in mice. In the present study, we report on the protective effect of Kp in fatal anaphylactic shock, likewise a Th2-driven immunopathology, and the identification of its active component. Mice daily treated with oral Kp during hypersensitization with ovalbumin were all protected against death when challenged with the allergen, as compared with the 100% mortality in the untreated group. A single… CONTINUE READING
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