Immunomodulatory effects of probiotic bacteria DNA: IL-1 and IL-10 response in human peripheral blood mononuclear cells.

@article{Lammers2003ImmunomodulatoryEO,
  title={Immunomodulatory effects of probiotic bacteria DNA: IL-1 and IL-10 response in human peripheral blood mononuclear cells.},
  author={Karen Manon Lammers and Patrizia Brigidi and Beatrice Vitali and Paolo Gionchetti and Fernando Rizzello and Elisabetta Caramelli and Diego Matteuzzi and Massimo Campieri},
  journal={FEMS immunology and medical microbiology},
  year={2003},
  volume={38 2},
  pages={
          165-72
        }
}
A new therapeutic approach for inflammatory bowel diseases is based on the administration of probiotic bacteria. Prokaryotic DNA contains unmethylated CpG motifs which can activate immune responses, but it is unknown whether bacterial DNA is involved in the beneficial effects obtained by probiotic treatment. Peripheral blood mononuclear cells (PBMC) from healthy donors were incubated with pure DNA of eight probiotic strains and with total bacterial DNA from human feces collected before and… CONTINUE READING
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