Immunomodulatory effects of poly(I,C)-LC in cancer patients.

  title={Immunomodulatory effects of poly(I,C)-LC in cancer patients.},
  author={Annette E. Maluish and Janet W. Reid and Eva A. Crisp and Wesley Overton and Hilton Levy and Kenneth A. Foon and Ronald B. Herberman},
  journal={Journal of biological response modifiers},
  volume={4 6},
Poly(I,C)-LC was administered in low (1 mg/m2) and intermediate (4 mg/m2) doses to cancer patients by intramuscular injection or intravenous infusion to evaluate the immunomodulatory effects. Natural killer cell (NK) activity was elevated slightly at the low dose and remained unchanged overall, but some depression was observed at the 4 mg/m2 intravenous dose. Monocyte function was elevated in all groups of patients, as was the interferon-induced enzyme 2'5'-oligo-A synthetase. These increases… CONTINUE READING

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