Immunomodulatory effects of nitrosoureas on the phenotype and functions of T cells in the thymus and periphery.

  title={Immunomodulatory effects of nitrosoureas on the phenotype and functions of T cells in the thymus and periphery.},
  author={Sara Reed Clary and Prakash S. Nagarkatti and Mitzi Nagarkatti},
  volume={20 3},

Effect of radon on the immune system: alterations in the cellularity and functions of T cells in lymphoid organs of mouse.

The studies demonstrating immunological alterations suggest an indirect effect of radon exposure that may have significant repercussions on the development of hypersensitivity and increased susceptibility to infections and cancer in the lung.

Use of the Immune System to Investigate the Toxicity Induced by Environmental Pollutants in Fish, Amphibian, and Mammalian Species

Investigating the toxicity induced by certain environmental pollutants on the immune systems of fish, amphibians, and mice found immunotoxicity of the tilapian immune system was detectable using mitogen-induced proliferation assay and cell-mediated toxicity assay.

Disease progression in recurrent glioblastoma patients treated with the VEGFR inhibitor axitinib is associated with increased regulatory T cell numbers and T cell exhaustion

It is suggested that axitinib treatment in patients with recurrent glioblastoma has a favorable impact on immune function, and the role of axit inib as potential combination partner with immunotherapy is investigated.



Immunomodulation by various nitrosoureas and its effect on the survival of the murine host bearing a syngeneic tumor.

The present study suggests that the outcome of chemotherapy with nitrosoureas depends, in addition to the tumoricidal activity of the drug, on the immunomodulating action on the immune mechanisms of the host.

Characterization of tumor-infiltrating CD4+ T cells as Th1 cells based on lymphokine secretion and functional properties.

The data suggest that in the LSA tumor model, the tumor-infiltrating CD4+ T cells have the properties of Th1 cells and these cells can mediate tumor-rejection independent of the CD8- T cells by activating the macrophages.

The role of suppressor T cells in BCNU-mediated rejection of a syngeneic tumor.

The present study suggests that, in addition to its direct tumoricidal activity, BCNU inhibits the induction of tumor-specific Ts, thereby explaining why a high percentage of mice survive a primary syngeneic tumor challenge after treatment withBCNU, and also resist subsequent rechallenge with the homologous tumor.

Increased cytotoxic sensitivity of YPC-1 tumor cells from mice treated with nitrosoureas.

It is hypothesized that the nitrosoureas have a dual mode of immunotherapeutic activity, which prevents fibrin from covering up or coating the tumor cells and preventing the ability of sensitized effector cells to recognize the tumor-specific antigens in association with self H-2 antIGens.

Abnormal differentiation of thymocytes in mice treated with cyclosporin A

It is reported here that irradiated mice given repeated injections of CsA show striking dysfunction of the thymus, andCsA seems to block the differentiation of immature CD4+CD8- and CD4-CD8+ cells expressing a high density of T-cell receptors and CD3 molecules.

Chlorozotocin, 2-(3-(2-chloroethyl)-3-nitrosoureido)-D-glucopyranose, an antitumor agent with modified bone marrow toxicity.

If the antitumor activity and reduced bone marrow toxicity of chlorozotocin are confirmed in man the use of this compound would facilitate treatment of patients with neoplastic disease who have preexisting abnormal bone marrow function or would allow for the more effective use of a nitrosourea agent in combination with anticancer agents possessing more potent myelosuppressive properties.

Expression of the J11d marker on peripheral T lymphocytes of MRL-lpr/lpr mice.

The present study suggests that a significant number of peripheral double-negative T cells of lpr mice bear the immature thymic differentiation Ag J11d, which is similar to that found in the control MRL +/+ mice.