Immunomodulatory effects of deacetylase inhibitors: therapeutic targeting of FOXP3+ regulatory T cells

@article{Wang2009ImmunomodulatoryEO,
  title={Immunomodulatory effects of deacetylase inhibitors: therapeutic targeting of FOXP3+ regulatory T cells},
  author={Liqing Wang and Edwin F. de Zoeten and M ichael Greene and Wayne W Hancock},
  journal={Nature Reviews Drug Discovery},
  year={2009},
  volume={8},
  pages={969-981}
}
Classical zinc-dependent histone deacetylases (HDACs) catalyse the removal of acetyl groups from histone tails and also from many non-histone proteins, including the transcription factor FOXP3, a key regulator of the development and function of regulatory T cells. Many HDAC inhibitors are in cancer clinical trials, but a subset of HDAC inhibitors has important anti-inflammatory or immunosuppressive effects that might be of therapeutic benefit in immuno-inflammatory disorders or post… CONTINUE READING