Immunomodulatory effects of black cohosh (Actaea racemosa) extract in female B6C3F1/N mice.

  title={Immunomodulatory effects of black cohosh (Actaea racemosa) extract in female B6C3F1/N mice.},
  author={Matthew J. Smith and Dori R. Germolec and Rachel P Frawley and Kimber L. White},
Black cohosh extracts (BCE; Actaea racemosa) are being used worldwide as an alternative to hormone replacement therapy for the management of menstrual and menopausal symptoms, yet the effects of BCE on the immune system are largely unknown. Female B6C3F1/N mice were treated daily with BCE (0, 62.5, 125, 250, 500, or 1000mg/kg) for 28 days by oral gavage. Liver weights were significantly increased (26-32%) at the 1000mg/kg dose. Dose-related increases in mean corpuscular volume and mean… CONTINUE READING
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