Immunomodulatory effects of betulinic acid from the bark of white birch on mice

  title={Immunomodulatory effects of betulinic acid from the bark of white birch on mice},
  author={Jin-e Yi and Bożena Obmińska-Mrukowicz and Li-yun Yuan and Hui Yuan},
  booktitle={Journal of veterinary science},
The objective of this study was to explore the immunomodulatory effects of betulinic acid (BA) extracted from the bark of white birch on mice. Female mice were orally administered BA for 14 days in doses of 0, 0.25, 0.5, and 1 mg/kg body weight. We found that BA significantly enhanced the thymus and spleen indices, and stimulated lymphocyte proliferation induced by Concanavalin A and lipopolysaccharide as shown by MTT assay. Flow cytometry revealed that BA increased the percentage of CD4… CONTINUE READING
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