Immunomodulatory effects of Toll-like receptor-7 activation on chronic lymphocytic leukemia cells

@article{Spaner2006ImmunomodulatoryEO,
  title={Immunomodulatory effects of Toll-like receptor-7 activation on chronic lymphocytic leukemia cells},
  author={David E. Spaner and Yonghong Shi and Dionne White and J. Pert{\'i}{\~n}ez Mena and Caitlin M Hammond and Jelena Tomic and Liwei He and Mark A. Tomai and Richard L. Miller and James W D Booth and Laszlo G. Radvanyi},
  journal={Leukemia},
  year={2006},
  volume={20},
  pages={286-295}
}
Weak immunogenicity of chronic lymphocytic leukemia (CLL) cells may contribute to disease progression and inhibit effective immunotherapy. Accordingly, agents that enhance the immunogenicity of CLL cells may be useful in immunotherapeutic approaches to this disease. Since Toll-like receptors (TLRs) are major regulators of innate immunity and initiation of adaptive immunity, we studied the effects of viral pathogen associated molecular pattern agonists (that are recognized by TLRs) on the… CONTINUE READING