Immunomodulatory effects of 1,25-dihydroxyvitamin D3 on TH1/TH2 cytokines in inflammatory bowel disease: an in vitro study.

@article{Ardizzone2009ImmunomodulatoryEO,
  title={Immunomodulatory effects of 1,25-dihydroxyvitamin D3 on TH1/TH2 cytokines in inflammatory bowel disease: an in vitro study.},
  author={Sandro Ardizzone and Andrea Cassinotti and Daria Trabattoni and Guendalina Manzionna and Veronica Rainone and M. Bevilacqua and Alessandro Massari and Ga{\"e}l Manes and Giovanni Maconi and Mario Clerici and Gabriele Bianchi Porro},
  journal={International journal of immunopathology and pharmacology},
  year={2009},
  volume={22 1},
  pages={63-71}
}
Crohn's disease (CD) is associated with a higher type-1-helper T cell (Th1) cytokine expression, whereas ulcerative colitis (UC) appears to express a modified Th2 response. In addition to its classic role in calcium homeostasis, calcitriol, the hormonal active form of vitamin D, exerts immunoregulatory effects such as modulation of Th1/Th2 cytokines. Therefore, calcitriol administration could modify immune dysfunction in CD and UC. Nine patients with UC (M/F: 5/4; mean age 47 years, remission(R… CONTINUE READING

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