Immunomodulatory effect of fosfomycin on human B-lymphocyte function.

  title={Immunomodulatory effect of fosfomycin on human B-lymphocyte function.},
  author={K. Morikawa and F. Oseko and S. Morikawa},
  journal={Antimicrobial Agents and Chemotherapy},
  pages={270 - 275}
  • K. Morikawa, F. Oseko, S. Morikawa
  • Published 1993
  • Biology, Medicine
  • Antimicrobial Agents and Chemotherapy
  • Fosfomycin (FOM) is an unique antibiotic which is chemically unrelated to any other known antimicrobial agent. Recent investigations have demonstrated that FOM inhibits histamine release from basophils. In this study, we examined the effect of FOM on human B-cell functions. FOM inhibited the proliferative response of resting B cells induced by Staphylococcus aureus Cowan 1 in a dose-dependent manner. FOM interfered with the transition from the G0 to the G1 phase of the cell cycle, leading to… CONTINUE READING
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