Immunomodulatory effect of diethylcarbamazine citrate plus filarial excretory-secretory product on rat hepatocarcinogenesis.

@article{AbdelLatif2015ImmunomodulatoryEO,
  title={Immunomodulatory effect of diethylcarbamazine citrate plus filarial excretory-secretory product on rat hepatocarcinogenesis.},
  author={Mahmoud Abdel-Latif and Thabet Farrag Sakran and Gamal El-Shahawi and Hoda El-Fayoumi and Al-Mahy El-Mallah},
  journal={International immunopharmacology},
  year={2015},
  volume={24 2},
  pages={
          173-181
        }
}
Enhancement of Anti-allergic Effect of Diethylcarbamazine Citrate in Asthmatic Mouse Model: Testing of Anti-drug Antibodies and Quercetin.
TLDR
The present data revealed high levels of Th2 cytokines (IL-4 and IL-5) and IgE in the Ova group and Qur at 40 mg/Kg could be recommended to enhance the DEC effect suggesting a novel approach for treatment.
Coenzyme Q10 attenuates rat hepatocarcinogenesis via the reduction of CD59 expression and phospholipase D activity
TLDR
In conclusion, CoQ10 could protect against rat HCC through increased lipids and the reduction of CD59 expression and PLD activity after treatment with Coenzyme Q10.
Identification of the complement 9‐binding protein in Setaria equina excretory‐secretory products
TLDR
S equina OV‐16 is the complement regulatory protein by its ability to bind C9 and inhibit the classical and alternative pathways of complement activation.
The Secretome of Filarial Nematodes and Its Role in Host-Parasite Interactions and Pathogenicity in Onchocerciasis-Associated Epilepsy
TLDR
The current knowledge regarding the components of the excretory-secretory products of filarial parasites and their bioactive functions in the human host are summarized and the pathogenic potential of the identified components in the pathophysiology of onchocerciasis-associated epilepsy is discussed.
Evaluation of inflammatory cytokines and oxidative stress markers in prostate cancer patients undergoing curative radiotherapy
TLDR
The results are highly suggestive that there is a specific cytokine response in patients undergoing curative radiotherapy for prostate cancer.
Detection for cross-reactive proteins in filarial worm Setaria equina, MCF-7 human breast cancer, and Huh-7 hepatoma cells
TLDR
The results indicated cross-reactive bands at 70 and 75 kDa in all extracts by anti-DEC and SeqE antibodies, respectively, and the expression of 70 kDa protein was only reduced in filarial worms and Huh-7 after in vitro DEC treatment compared to the control.

References

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Effect of Diethylcarbamazine Citrate and Setaria equina Excretory–Secretory Material on Rat Hepatocellular Carcinoma
TLDR
The target of this study was to examine the effect of DEC, excretory–secretory (ES) material from the filarial parasite Setaria equina or a combination of both on the status of oxidative stress and pathogenesis of rat hepatocellular carcinoma (HCC) induced by diethylnitrosamine and 2-acetylaminofluorene.
Diethylcarbamazine (DEC): immunopharmacological interactions of an anti-filarial drug
TLDR
The evidence for an indirect mode of action for one major anti-filarial drug, diethylcarbamazine (DEC), is discussed, and the interpretation most consistent with existing data is that DEC alters arachidonic acid metabolism in microfilariae and in host endothelial cells.
Null anticarcinogenic effect of silymarin on diethylnitrosamine-induced hepatocarcinogenesis in rats
TLDR
Results indicate that silymarin may not be considered as a candidate agent against hepatocarcinogenesis, and the expression levels of proliferating cell nuclear antigen and glutathione S-transferase P, which are hepatOCarcinogenic markers, were not significantly modified by the sily marin treatment.
Macrofilaricidal activity of metabolites of diethylcarbamazine.
TLDR
In the rodent and in man, the antifilarial action of DEC is swift and of short duration, but in some human filariasis i.e. loaiasis, lymphatic filARIasis, the spectrum of DEC activities extends to adult filaria.
Excretory-Secretory Products from Hookworm L3 and Adult Worms Suppress Proinflammatory Cytokines in Infected Individuals
TLDR
It is suggested that hookworm ES products downmodulate proliferative responses and inflammation during the chronic phase of the disease and facilitate early larval survival or adult worm persistence in the gut.
Antigens from Ascaris suum trigger in vitro macrophage NO production
TLDR
In vitro incubation of macrophages with SA and SL3 antigens of A. suum did not result in NO release from cells, whereas incubation with ESA or ESL3 antIGens resulted in the stimulation of NO production by these cells, both in a specific and dose‐dependent manner.
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TLDR
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TLDR
The hatching associated materials from filarial parasite S. digitata showed immunosuppression in BALB/C mice on immunization and protein from lysate of embryo zone from which ES materials were released along with the release of mf originate, showed generalized immunopotentiation, suggesting a change in the nature of materials of embryonic origin before and after the releaseof mf.
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