Immunomodulatory constituents from an ascomycete, Emericella aurantio-brunnea.

  title={Immunomodulatory constituents from an ascomycete, Emericella aurantio-brunnea.},
  author={H. Fujimoto and E. Nakamura and E. Okuyama and M. Ishibashi},
  journal={Chemical & pharmaceutical bulletin},
  volume={48 10},
Fractionation monitored by the immunomodulatory activity of the AcOEt extract of an Ascomycete, Emericella aurantio-brunnea, afforded two known fungal sesterterpenes, variecolin (1) and variecolactone (2), two new variecolin congeners named variecoacetals A (3) and B (4), and a new sesquiterpenetriol diester named emeremophiline (5), as the immunosuppressive constituents of this fungus. The absolute configuration of 1, which was previously not determined, was determined to be (2S,3S,6R,10S,11R… Expand
16 Citations
Immunomodulatory constituents from Ascomycetous fungi
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  • Journal of Natural Medicines
  • 2017
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Construction of the basic skeleton of ophiobolin A and variecolin.
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Releasing the potential power of terpene synthases by a robust precursor supply platform.
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Total synthesis of sesterterpenoids.
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Fungal metabolites II
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