Immunomodulatory activity of a protein isolated from garlic extract on delayed type hypersensitivity.

@article{Ghazanfari2002ImmunomodulatoryAO,
  title={Immunomodulatory activity of a protein isolated from garlic extract on delayed type hypersensitivity.},
  author={Tooba Ghazanfari and Zuhair Mohammad Hassan and Marzieh Ebrahimi},
  journal={International immunopharmacology},
  year={2002},
  volume={2 11},
  pages={
          1541-9
        }
}
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66 Citations
Highly Influential Citations
1
Background Citations
23
Methods Citations
5
Results Citations
4

66 Citations

Immunomodulatory Attributes of Aged Garlic Extract and Its Components
Immunomodulatory affect of R10 fraction of garlic extract on natural killer activity.
Evaluation of the immunomodulatory effect of the 14 kDa protein isolated from aged garlic extract on dendritic cells.
Effect of 14-kDa and 47-kDa protein molecules of age garlic extract on peritoneal macrophages
Introduction: Garlic (Allium sativum), traditionally being used as a spice worldwide, has different applications and is claimed to possess beneficial effects in several health ailments such as tumor…
The 14 kDa Protein Molecule Isolated from Garlic Suppresses Indoleamine 2 , 3-Dioxygenase Metabolites in Mononuclear Cells In vitro
TLDR
A significant down-regulatory effect of garlic on IDO activity was found and also the proliferation responses of mononuclear cells increased, which paves the way for elucidating its specific therapeutic effect in preventing tumor progress.
Immunomodulation and Anti-Inflammatory Effects of Garlic Compounds
The benefits of garlic to health have been proclaimed for centuries; however, only recently have Allium sativum and its derivatives been proposed as promising candidates for maintaining the…
Identity of the immunomodulatory proteins from garlic (Allium sativum) with the major garlic lectins or agglutinins.
Identification of the protein components displaying immunomodulatory activity in aged garlic extract.
Evaluation of the Effect of the 47 kDa Protein Isolated from Aged Garlic Extract on Dendritic Cells
TLDR
It is found that 47 kDa protein purified from AGE can be considered as a potential candidate to generate tolerogenic DCs in vitro and down regulated the expression of costimulatory and MHC-II surface molecules, which is similar to tolerogenicDC phenotype.
The 14kDa protein molecule isolated from garlic suppresses indoleamine 2, 3-dioxygenase metabolites in mononuclear cells in vitro.
TLDR
A significant down-regulatory effect of garlic on IDO activity was found and also the proliferation responses of mononuclear cells increased, which paves the way for elucidating its specific therapeutic effect in preventing tumor progress.
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References

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Garlic Induces a Shift in Cytokine Pattern in Leishmania major‐Infected BALB/c Mice
The regulation of T helper (Th)1‐ and Th2‐type cytokine patterns is important in the final outcome of leishmaniasis in human and murine models. We examined the efficacy of garlic therapy or a…
Protective effects of diallyl sulfide on N-nitrosodimethylamine-induced immunosuppression in mice.
[The preventing function of garlic on experimental oral precancer and its effect on natural killer cells, T-lymphocytes and interleukin-2].
In order to study the effect and mechanism of garlic on preventing oral precancer, we divided randomly 32 Wistar rats into two groups. The garlic group was painted with garlic solution on the hard…
[Chronic toxicity test of garlic extract in rats].
TLDR
There were no toxic symptoms due to garlic extract even at dose level of 2000 mg/kg for 5 times a week during 6 months and no toxic signs were observed on any of the tissues and organs examined.
Chemoprevention of 1,2-dimethylhydrazine-induced colon cancer in mice by naturally occurring organosulfur compounds.
TLDR
Data indicate that the allyl group coupled to a single sulfur atom might play an important structural role in inhibition of DMH-induced colonic nuclear toxicity and carcinogenesis, and might assist in detoxification of carcinogens and could be necessary for some aspects of chemoprevention.
[Acute toxicity test of garlic extract].
TLDR
The acute toxicity toxicity test of garlic extract was studied in Wistar rats and ddY mice and no specific signs due to garlic extract were observed in survivals for 7 days.
Effects of garlic compounds diallyl sulfide and diallyl disulfide on arylamine N-acetyltransferase activity in strains of Helicobacter pylori from peptic ulcer patients.
TLDR
This report is the first demonstration that garlic components can affect H. pylori growth and NAT activity, and demonstrates that DAS or DADS elicited dose-dependent bactericide affects on H.pylori cultures.
Effects of organosulfur compounds from garlic and onions on benzo[a]pyrene-induced neoplasia and glutathione S-transferase activity in the mouse.
TLDR
The fact that in the lung the monosulfide and disulfide inhibited, but the trisulfide did not inhibit, indicates that the number of sulfur atoms in the molecule can control the organ sites at which protection against carcinogenesis will occur.
Allicin, a naturally occurring antibiotic from garlic, specifically inhibits acetyl‐CoA synthetase
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