Immunomodulatory action of levofloxacin on cytokine production by human peripheral blood mononuclear cells.

  title={Immunomodulatory action of levofloxacin on cytokine production by human peripheral blood mononuclear cells.},
  author={Tomoaki Yoshimura and Chikako Kurita and Eiseki Usami and Toshiya Nakao and S. Watanabe and Joji Kobayashi and Futoshi Yamazaki and Hiroichi Nagai},
  volume={42 6},
Levofloxacin (LVFX), the bacteriologically active isomer of ofloxacin, is a fluorinated quinolone. LVFX suppressed the proliferative activity of peripheral blood mononuclear cells (PBMC) stimulated with phytohemagglutinin (PHA). LVFX increased interleukin-2 (IL-2) production by PBMC stimulated with PHA in a dose-dependent manner, with more than 10 micrograms/ml of LVFX causing a significant increase. The granulocyte-macrophage colony-stimulating factor and soluble IL-2 receptor production by… 
Immunomodulating Activity of Quinolones: Review
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In contrast, quinolones inhibit both human and mouse monocytic IL-1 and TNF-α synthesis, an effect that is beneficial in rat experimental type II collagen induced arthritis and LPS-induced septic chock in mice.
Effects of antimicrobial agents on spontaneous and endotoxin-induced cytokine release of human peripheral blood mononuclear cells
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Immunomodulatory Action of Levofloxacin on Cytokine Production in Adults with Community-Acquired Pneumonia
Treatment with levofloxacin showed significant inhibitory effect of TNF- α as a pro- inflammatory cytokine and a significant stimulatory effect of IL-10 as an anti-inflammatory cytokines which may provide additional benefits in treatment of respiratory tract infections and more efficient eradication of the offending pathogen especially with the emergence of multi-drug resistant microbes.
Immunomodulatory effects of quinolones.
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The 6-Fluoro-8-Methoxy Quinolone Gatifloxacin Down-Regulates Interleukin-8 Production in Prostate Cell Line PC-3
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Systemic Expression of Cytokine Production in Patients with Severe Pneumococcal Pneumonia: Effects of Treatment with a β-Lactam versus a Fluoroquinolone
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