Immunomodulatory action of levofloxacin on cytokine production by human peripheral blood mononuclear cells.

@article{Yoshimura1996ImmunomodulatoryAO,
  title={Immunomodulatory action of levofloxacin on cytokine production by human peripheral blood mononuclear cells.},
  author={Tomoaki Yoshimura and Chikako Kurita and Eiseki Usami and Toshiya Nakao and S. Watanabe and Joji Kobayashi and Futoshi Yamazaki and Hiroichi Nagai},
  journal={Chemotherapy},
  year={1996},
  volume={42 6},
  pages={
          459-64
        }
}
Levofloxacin (LVFX), the bacteriologically active isomer of ofloxacin, is a fluorinated quinolone. LVFX suppressed the proliferative activity of peripheral blood mononuclear cells (PBMC) stimulated with phytohemagglutinin (PHA). LVFX increased interleukin-2 (IL-2) production by PBMC stimulated with PHA in a dose-dependent manner, with more than 10 micrograms/ml of LVFX causing a significant increase. The granulocyte-macrophage colony-stimulating factor and soluble IL-2 receptor production by… 
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