Immunomodulatory Functions Encoded by the E3 Transcription Unit of Adenoviruses

  title={Immunomodulatory Functions Encoded by the E3 Transcription Unit of Adenoviruses},
  author={Hans-gerhard Burgert and Ju¨rgen H. Blusch},
  journal={Virus Genes},
Persistent viruses have evolved multiple strategies to escape the host immune system. One important prerequisite for efficient viral reproduction in the face of an ongoing immune response is prevention of premature lysis of infected cells. A number of viruses achieve this goal by interfering with antigen presentation and recognition of infected cells by cytotoxic T cells (CTL). Another viral strategy aims to block apoptosis triggered by host defense mechanisms. Both types of strategies seem to… CONTINUE READING

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