Immunomodulation with low-dose immunoglobulins for moderate IgA nephropathy and Henoch-Schönlein purpura. Preliminary results of a prospective uncontrolled trial.

@article{Rostoker1995ImmunomodulationWL,
  title={Immunomodulation with low-dose immunoglobulins for moderate IgA nephropathy and Henoch-Sch{\"o}nlein purpura. Preliminary results of a prospective uncontrolled trial.},
  author={Guy Rostoker and D Desvaux-Belghiti and Yannick Pilatte and M Petit-Phar and C A Philippon and Lionel Deforges and H Terzidis and Liliane Intrator and Charles Andre and Serge Adnot},
  journal={Nephron},
  year={1995},
  volume={69 3},
  pages={327-34}
}
Recently, our group has shown that a 3-month course of intravenous immunoglobulin (2 g/kg/monthly) followed by 6 months of intramuscular immunoglobulins (IMIG, 16.5%, 0.35 ml/kg every 15 days) was able to slow or to stop the decline in the glomerular filtration rate, to reduce proteinuria, hematuria, leukocyturia and the histological index of activity on renal biopsy in patients with severe forms of IgA nephropathy (IGAN) and Henoch-Schönlein purpura (HSP). The aim of this open prospective… CONTINUE READING

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