Immunomodulation using genetically engineered bacteria for type III-mediated delivery of heterologous antigens and cytokines: potential application in vaccine and therapeutical developments.

The rational design of new approaches aiming to improve antigen or drug delivery remains a major challenge in numerous vaccine and therapeutical strategies. Studies on genetically engineered bacteria have led to significant progress in the delivery of heterologous proteins. Yet, the efficiency of such recombinant bacteria relies particularly on their… CONTINUE READING