Immunomodulation of the tumor microenvironment by neutralization of Semaphorin 4D
@article{Evans2015ImmunomodulationOT, title={Immunomodulation of the tumor microenvironment by neutralization of Semaphorin 4D}, author={E. Evans and M. Paris and E. Smith and M. Zauderer}, journal={Oncoimmunology}, year={2015}, volume={4} }
Semaphorin 4D is highly expressed at the invasive tumor margin and acts as a guidance molecule, restricting movement of tumoricidal immune cells into the tumor microenvironment. We recently showed that antibody neutralization of SEMA4D augmented activated monocyte and anticancer T-cell tumor penetration and that anti-SEMA4D antibody potentiated other immunomodulatory therapies in murine tumor models.
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