Immunomodulation of the tumor microenvironment by neutralization of Semaphorin 4D

@article{Evans2015ImmunomodulationOT,
  title={Immunomodulation of the tumor microenvironment by neutralization of Semaphorin 4D},
  author={E. Evans and M. Paris and E. Smith and M. Zauderer},
  journal={Oncoimmunology},
  year={2015},
  volume={4}
}
Semaphorin 4D is highly expressed at the invasive tumor margin and acts as a guidance molecule, restricting movement of tumoricidal immune cells into the tumor microenvironment. We recently showed that antibody neutralization of SEMA4D augmented activated monocyte and anticancer T-cell tumor penetration and that anti-SEMA4D antibody potentiated other immunomodulatory therapies in murine tumor models. 
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