• DOI:10.1080/2162402X.2015.1054599
Corpus ID: 16979949.oa

Immunomodulation of the tumor microenvironment by neutralization of Semaphorin 4D

@inproceedings{Evans2015ImmunomodulationOT,
  title={Immunomodulation of the tumor microenvironment by neutralization of Semaphorin 4D},
  author={Elizabeth E. Evans and Mark Eliot Paris and Ernest S. Smith and Maurice Zauderer},
  booktitle={Oncoimmunology},
  year={2015}
}

Elizabeth E. Evans, Mark Eliot Paris, +1 author Maurice Zauderer

Published in Oncoimmunology 2015

Biology, Medicine

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Semaphorin 4D is highly expressed at the invasive tumor margin and acts as a guidance molecule, restricting movement of tumoricidal immune cells into the tumor microenvironment. We recently showed that antibody neutralization of SEMA4D augmented activated monocyte and anticancer T-cell tumor penetration and that anti-SEMA4D antibody potentiated other immunomodulatory therapies in murine tumor models.