Immunomodulation of human monocytes following exposure to Lutzomyia intermedia saliva

@article{Menezes2007ImmunomodulationOH,
  title={Immunomodulation of human monocytes following exposure to Lutzomyia intermedia saliva},
  author={Maria Jos{\'e} C Menezes and Dirceu Joaquim Costa and Jorge Clar{\^e}ncio and Jos{\'e} Carlos Miranda and Aldina Barral and Manoel Barral-Netto and Cl{\'a}udia Ida Brodskyn and Camila I de Oliveira},
  journal={BMC Immunology},
  year={2007},
  volume={9},
  pages={12 - 12}
}
Sand fly saliva contains potent and complex pharmacologic molecules that are able to modulate the host's hemostatic, inflammatory, and immune systems. In this study, we evaluated the effects of salivary gland sonicate (SGS) of Lutzomyia intermedia, the natural vector of Leishmania braziliensis, on monocytes obtained from the peripheral blood mononuclear cells (PBMC) of healthy volunteers. We investigated the effects of sand fly saliva on cytokine production and surface molecule expression of… CONTINUE READING