Immunomodulation of allergic disease.

  title={Immunomodulation of allergic disease.},
  author={David H. Broide},
  journal={Annual review of medicine},
This review focuses on sublingual immunotherapy (SLIT), toll-like receptor-9 (TLR-9) vaccines using cytosine phosphorothioate guanosine (CpG)-allergen conjugates, and anti-IL-5 as novel immunomodulating therapies in allergy. At present, all three approaches are investigational in the United States and require further study to determine their safety and effectiveness. SLIT provides a novel oral route of administering an allergen to induce tolerance to inhaled allergens. Studies of SLIT in… CONTINUE READING
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Effects of an interleukin-5 blocking monoclonal antibody on eosinophils, airway hyper-responsiveness, and the late asthmatic response

  • M Leckie, A Brinke, J Khan
  • Lancet
  • 2000
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