Immunomodulation of Fungal β-Glucan in Host Defense Signaling by Dectin-1

@article{Batbayar2012ImmunomodulationOF,
  title={Immunomodulation of Fungal $\beta$-Glucan in Host Defense Signaling by Dectin-1},
  author={Sainkhuu Batbayar and Dong Hee Lee and Ha Won Kim},
  journal={Biomolecules \& Therapeutics},
  year={2012},
  volume={20},
  pages={433 - 445}
}
During the course of evolution, animals encountered the harmful effects of fungi, which are strong pathogens. Therefore, they have developed powerful mechanisms to protect themselves against these fungal invaders. β-Glucans are glucose polymers of a linear β(1,3)-glucan backbone with β(1,6)-linked side chains. The immunostimulatory and antitumor activities of β-glucans have been reported; however, their mechanisms have only begun to be elucidated. Fungal and particulate β-glucans, despite their… 

Figures and Tables from this paper

Beta-Glucans from Fungi: Biological and Health-Promoting Potential in the COVID-19 Pandemic Era
TLDR
This review summarizes the latest findings on biological and health-promoting potential of mushroom beta-glucans for the treatment of civilization and viral diseases, with particular emphasis on COVID-19.
Potential role of mushroom beta-glucans in immunity and inflammation in viral infections and COVID-19
TLDR
Understanding whether the TRIM processes are responsible for antiviral responses will undoubtedly provide a deeper understanding of other potential antiviral strategies, as the new SARS-CoV-2 is not the first- or last-time humanity has to deal with viral pandemics.
Yeast-Derived β-Glucan in Cancer: Novel Uses of a Traditional Therapeutic
TLDR
It is suggested that β-glucan may play an essential role in future strategies to prevent and inhibit tumor growth and the emerging success of combinatorial approaches to cancer treatment involving β- glucan is suggested.
Characterization of Anti-Fungal Inflammasome Responses and the Role of Caspase-8 in Innate Immune Signaling: A Dissertation
TLDR
It is demonstrated that C. albicans induced IL-1β production is strictly dependent on the phagocytosis of the fungus and the NLRP3 inflammasome and its associated components, ASC and caspase-1.
Fungal polysaccharides.
Molecular Interactions of β-(1→3)-Glucans with Their Receptors
TLDR
This review focuses on the variety of elucidated molecular interactions that involve these natural or synthetic polysaccharides and their receptors, i.e., Dectin-1, CR3, glycolipids, langerin and carbohydrate-binding modules.
Could the Induction of Trained Immunity by β-Glucan Serve as a Defense Against COVID-19?
TLDR
It is hypothesized that the use of oral β-glucan in a prophylactic setting could be an effective way to boost immune responses and abrogate symptoms in COVID-19, though clinical trials are necessary to confirm the efficacy of this treatment and to further examine differential effects of β- glucan's from various sources.
Shaping the Innate Immune Response by Dietary Glucans: Any Role in the Control of Cancer?
TLDR
The regulatory effects of dietary β-glucans on human innate immunity cells are reviewed, their potential role in cancer control is discussed and their potential candidates as adjuvants in antitumor therapies as well as in cancer prevention strategies are discussed.
C-type lectin receptor-mediated immune recognition and response of the microbiota in the gut
TLDR
The roles of CLRs in maintaining gastrointestinal immune-system homeostasis, especially their functions in mediating immune recognition and responses in the gut are summarized, and the significance of CLR-mediated sensing of microbial and non-microbial compounds in the Gut immune system is highlighted.
...
...

References

SHOWING 1-10 OF 139 REFERENCES
Dectin-1 is required for β-glucan recognition and control of fungal infection
TLDR
It is shown that deficiency of dectin-1, the myeloid receptor for β-glucan, rendered mice susceptible to infection with Candida albicans, and a signaling non–Toll-like pattern-recognition receptor required for the induction of protective immune responses is established.
The role of Dectin-1 in the host defence against fungal infections.
(1,3)-β-Glucans Activate Both Dectin-1 and NLRP3 Inflammasome in Human Macrophages
TLDR
The results show that β-glucans are recognized by membrane-associated dectin-1 and cytoplasmic NLRP3 inflammasome resulting in IL-1β gene transcription and IL- 1β secretion in human macrophages, respectively.
Fungal recognition is mediated by the association of dectin-1 and galectin-3 in macrophages
TLDR
Retrieval of sortagged dectin-1 expressed in macrophages uncovered a unique interaction between dectIn-1 and galectin-3 that functions in the proinflammatory response of macrophage to pathogenic fungi.
Pattern recognition: recent insights from Dectin-1
The Biological Role of Dectin-1 in Immune Response
TLDR
This paper focuses on the characteristics of dectin-1 and its biological role in immune response, which is involved in the adaptive immune response as well as autoimmune diseases and immune tolerance.
Dectin-1 and Dectin-2 in innate immunity against fungi.
TLDR
The structures, ligands, signal transduction and functional roles of DECTin-1 and Dectin-2 in host defense against fungal infection are reviewed.
Immune recognition: A new receptor for β-glucans
TLDR
This work identifies this unknown receptor on macrophages as dectin-1 (ref. 2), a finding that provides new insights into the innate immune recognition of β-glucans.
Differential pathways regulating innate and adaptive antitumor immune responses by particulate and soluble yeast-derived β-glucans.
TLDR
It is shown that yeast-derived particulate β-glucan activated dendritic cells (DCs) and macrophages via a C-type lectin receptor dectin-1 pathway, revealing the importance of different preparations of β- glucans in the adjuvant therapy and allow for the rational design of immunotherapeutic protocols usable in clinical trials.
Activation of the innate immune receptor Dectin-1 upon formation of a “phagocytic synapse”
TLDR
The ‘phagocytic synapse’ now provides a model mechanism by which innate immune receptors can distinguish direct microbial contact from detection of microbes at a distance, thereby initiating direct cellular antimicrobial responses only when they are required.
...
...