Immunomodulation of Fungal β-Glucan in Host Defense Signaling by Dectin-1

@article{Batbayar2012ImmunomodulationOF,
  title={Immunomodulation of Fungal $\beta$-Glucan in Host Defense Signaling by Dectin-1},
  author={Sainkhuu Batbayar and Dong Hee Lee and Ha Won Kim},
  journal={Biomolecules \& Therapeutics},
  year={2012},
  volume={20},
  pages={433 - 445}
}
During the course of evolution, animals encountered the harmful effects of fungi, which are strong pathogens. Therefore, they have developed powerful mechanisms to protect themselves against these fungal invaders. β-Glucans are glucose polymers of a linear β(1,3)-glucan backbone with β(1,6)-linked side chains. The immunostimulatory and antitumor activities of β-glucans have been reported; however, their mechanisms have only begun to be elucidated. Fungal and particulate β-glucans, despite their… 

Figures and Tables from this paper

Beta-Glucans from Fungi: Biological and Health-Promoting Potential in the COVID-19 Pandemic Era
TLDR
This review summarizes the latest findings on biological and health-promoting potential of mushroom beta-glucans for the treatment of civilization and viral diseases, with particular emphasis on COVID-19.
Yeast-Derived β-Glucan in Cancer: Novel Uses of a Traditional Therapeutic
TLDR
It is suggested that β-glucan may play an essential role in future strategies to prevent and inhibit tumor growth and the emerging success of combinatorial approaches to cancer treatment involving β- glucan is suggested.
Characterization of Anti-Fungal Inflammasome Responses and the Role of Caspase-8 in Innate Immune Signaling: A Dissertation
TLDR
It is demonstrated that C. albicans induced IL-1β production is strictly dependent on the phagocytosis of the fungus and the NLRP3 inflammasome and its associated components, ASC and caspase-1.
Fungal polysaccharides.
Molecular Interactions of β-(1→3)-Glucans with Their Receptors
TLDR
This review focuses on the variety of elucidated molecular interactions that involve these natural or synthetic polysaccharides and their receptors, i.e., Dectin-1, CR3, glycolipids, langerin and carbohydrate-binding modules.
Could the Induction of Trained Immunity by β-Glucan Serve as a Defense Against COVID-19?
TLDR
It is hypothesized that the use of oral β-glucan in a prophylactic setting could be an effective way to boost immune responses and abrogate symptoms in COVID-19, though clinical trials are necessary to confirm the efficacy of this treatment and to further examine differential effects of β- glucan's from various sources.
C-type lectin receptor-mediated immune recognition and response of the microbiota in the gut
TLDR
The roles of CLRs in maintaining gastrointestinal immune-system homeostasis, especially their functions in mediating immune recognition and responses in the gut are summarized, and the significance of CLR-mediated sensing of microbial and non-microbial compounds in the Gut immune system is highlighted.
Polysaccharides from the fungus Inonotus obliquus activate macrophages into a tumoricidal phenotype via interaction with TLR2, TLR4 and Dectin-1a
TLDR
The induction of tumoricidal activity in the macrophage as well as the interaction with TLR2, TLR4 and Dectin-1a suggest that the I. obliquus polysaccharides may have unique ways of interacting with macrophages, which could open up for new treatment options in cancer immunotherapy.
...
...

References

SHOWING 1-10 OF 139 REFERENCES
Dectin-1 is required for β-glucan recognition and control of fungal infection
TLDR
It is shown that deficiency of dectin-1, the myeloid receptor for β-glucan, rendered mice susceptible to infection with Candida albicans, and a signaling non–Toll-like pattern-recognition receptor required for the induction of protective immune responses is established.
The role of Dectin-1 in the host defence against fungal infections.
Fungal recognition is mediated by the association of dectin-1 and galectin-3 in macrophages
TLDR
Retrieval of sortagged dectin-1 expressed in macrophages uncovered a unique interaction between dectIn-1 and galectin-3 that functions in the proinflammatory response of macrophage to pathogenic fungi.
Pattern recognition: recent insights from Dectin-1
The Biological Role of Dectin-1 in Immune Response
TLDR
This paper focuses on the characteristics of dectin-1 and its biological role in immune response, which is involved in the adaptive immune response as well as autoimmune diseases and immune tolerance.
Dectin-1 and Dectin-2 in innate immunity against fungi.
TLDR
The structures, ligands, signal transduction and functional roles of DECTin-1 and Dectin-2 in host defense against fungal infection are reviewed.
Immune recognition: A new receptor for β-glucans
TLDR
This work identifies this unknown receptor on macrophages as dectin-1 (ref. 2), a finding that provides new insights into the innate immune recognition of β-glucans.
Differential pathways regulating innate and adaptive antitumor immune responses by particulate and soluble yeast-derived β-glucans.
TLDR
It is shown that yeast-derived particulate β-glucan activated dendritic cells (DCs) and macrophages via a C-type lectin receptor dectin-1 pathway, revealing the importance of different preparations of β- glucans in the adjuvant therapy and allow for the rational design of immunotherapeutic protocols usable in clinical trials.
Activation of the innate immune receptor Dectin-1 upon formation of a “phagocytic synapse”
TLDR
The ‘phagocytic synapse’ now provides a model mechanism by which innate immune receptors can distinguish direct microbial contact from detection of microbes at a distance, thereby initiating direct cellular antimicrobial responses only when they are required.
Relative Contributions of Dectin-1 and Complement to Immune Responses to Particulate β-Glucans
TLDR
Although Dectin-1 is necessary for optimal phagocytosis of GPs in the absence of complement, complement dominates when both an intact complement system and DectIn-1 are present.
...
...