Immunomodulation in vivo by the Mycoplasma arthritidis superantigen, MAM.

@article{Cole1993ImmunomodulationIV,
  title={Immunomodulation in vivo by the Mycoplasma arthritidis superantigen, MAM.},
  author={Bonnie Cole and Emily Ahmed and Barbara A. Araneo and J. D. Shelby and Craig D. Kamerath and Sheng Quan Wei and Shawna McCall and Curtis L. Atkin},
  journal={Clinical infectious diseases : an official publication of the Infectious Diseases Society of America},
  year={1993},
  volume={17 Suppl 1},
  pages={S163-9}
}
Mycoplasma arthritidis produces a potent superantigen (MAM) that activates specific murine and human T lymphocytes to proliferate and secrete lymphokines. We show here that MAM also influences both T- and B-cell functions in vivo. Lymphocytes from mice injected with MAM exhibit a suppression of proliferative responses to MAM in vitro but only a partial suppression of responses to other mitogens. This T-cell anergy not only decreased contact sensitivity to dinitrofluorobenzene but also prolonged… CONTINUE READING

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