Immunomodulation by theophylline in asthma. Demonstration by withdrawal of therapy.

  title={Immunomodulation by theophylline in asthma. Demonstration by withdrawal of therapy.},
  author={Joseph C. Kidney and Mercedes Dom{\'i}nguez and Paul M. Taylor and Marlene Rose and Kian Fan Chung and Peter J Barnes},
  journal={American journal of respiratory and critical care medicine},
  volume={151 6},
Theophylline is the most widely used anti-asthma drug worldwide and is classified as a bronchodilator, although there is increasing evidence that it may have immunomodulatory effects. We have investigated the effects of theophylline withdrawal under placebo control in 27 asthmatic patients (25 to 70 yr) treated with long-term theophylline who were also treated with high dose inhaled corticosteroids. We measured asthma symptoms (diary card), lung function (spirometry and home records of peak… CONTINUE READING


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