Immunomodulation by thalidomide and thalidomide analogues.

  title={Immunomodulation by thalidomide and thalidomide analogues.},
  author={Laura G. Corral and Gilla Kaplan},
  journal={Annals of the rheumatic diseases},
  volume={58 Suppl 1},
Tumour necrosis factor á (TNFá), a key cytokine involved in the host immune response, also contributes to the pathogenesis of both infectious and autoimmune diseases. To ameliorate the pathology resulting from TNFá in these clinical settings, strategies for the inhibition of this cytokine have been developed. Our previous work has shown that the drug thalidomide is a partial inhibitor of TNFá production in vivo. For example, when leprosy patients suVering from erythema nodosum leprosum (ENL… CONTINUE READING