Immunomodulation by polyaromatic hydrocarbons in mice and murine cells.

  title={Immunomodulation by polyaromatic hydrocarbons in mice and murine cells.},
  author={Ronald Blanton and Mark Lyte and Mr. Julie Elana Myers and Peter H. Bick},
  journal={Cancer research},
  volume={46 6},
Several functionally defined in vitro antibody generating systems were used to assess the immunomodulating mechanisms of the benzopyrenes. When benzo(a)pyrene (BaP) or benzo(e)pyrene (BeP) was incorporated into a T-dependent antibody (TDAb)-producing spleen cell culture system, dose- and time-dependent inhibition of plaque-forming cell responses was observed. Addition of BaP at concentrations as low as 0.002 microgram/ml (7.93 nM) resulted in suppression of the TDAb plaque-forming cell response… CONTINUE READING
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