Immunomodulation by n-3- versus n-6-rich lipid emulsions in murine acute lung injury--role of platelet-activating factor receptor.

@article{Schaefer2007ImmunomodulationBN,
  title={Immunomodulation by n-3- versus n-6-rich lipid emulsions in murine acute lung injury--role of platelet-activating factor receptor.},
  author={Martina Barbara Schaefer and Juliane Ott and Andrea Mohr and Ming Hua Bi and Andrea Grosz and Norbert Weissmann and Satoshi Ishii and Friedrich Grimminger and Werner Seeger and Konstantin Mayer},
  journal={Critical care medicine},
  year={2007},
  volume={35 2},
  pages={544-54}
}
OBJECTIVE Cytokines, platelet-activating factor (PAF), and eicosanoids control local and systemic inflammation. Conventional soybean oil-based lipid emulsions used for parenteral nutrition may aggravate the leukocyte inflammatory response or adhesion to the vessel wall. Fish oil-based lipid emulsions, in contrast, may exert an anti-inflammatory effect. DESIGN We investigated the impact of lipid emulsions on leukocyte invasion, protein leakage, and cytokines in two murine models of acute… CONTINUE READING

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