Immunomodulation by mesenchymal stem cells combats the foreign body response to cell-laden synthetic hydrogels.

Abstract

The implantation of non-biological materials, including scaffolds for tissue engineering, ubiquitously leads to a foreign body response (FBR). We recently reported that this response negatively impacts fibroblasts encapsulated within a synthetic hydrogel and in turn leads to a more severe FBR, suggesting a cross-talk between encapsulated cells and… (More)
DOI: 10.1016/j.biomaterials.2014.11.020

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