Immunomodulation by indoleamines: Serotonin and melatonin action on DNA and interferon-γ synthesis by human peripheral blood mononuclear cells

@article{Arzt1988ImmunomodulationBI,
  title={Immunomodulation by indoleamines: Serotonin and melatonin action on DNA and interferon-γ synthesis by human peripheral blood mononuclear cells},
  author={Eduardo Arzt and Silvia Fern{\'a}ndez-Castelo and Liliana M. E. Finocchiaro and Marcelo Criscuolo and Alberto Aceves Diaz and Samuel Finkielman and V{\'i}ctor E. Nahmod},
  journal={Journal of Clinical Immunology},
  year={1988},
  volume={8},
  pages={513-520}
}
Different concentrations of indoleamines, serotonin and melatonin, inhibited phytohemagglutinin stimulated DNA synthesis. Thus, 10−3 to 10−4 M of either indoleamine acted at the optimal phytohemagglutinin concentration, while 10−3 to 10−7 M acted at suboptimal phytohemagglutinin levels. The serotonin effect was reversed by the serotonergic S1-S2 receptor antagonist methysergide but not by the S2 antagonist ketanserin. This indicates that only the S1 receptor is involved in the inhibitory effect… CONTINUE READING