Immunomodulation after allogeneic bone marrow transplantation by CD4+CD25+ regulatory T cells.

@article{Hoffmann2005ImmunomodulationAA,
  title={Immunomodulation after allogeneic bone marrow transplantation by CD4+CD25+ regulatory T cells.},
  author={P. Hoffmann and Tina J. Boeld and Biserka Piseshka and M. Edinger},
  journal={Microbes and infection},
  year={2005},
  volume={7 7-8},
  pages={
          1066-72
        }
}
Graft-versus-host disease is a major complication after allogeneic bone marrow transplantation (BMT) caused by donor T cells. Immunosuppression mediated by CD4(+)CD25(+) regulatory T cells has been shown to ameliorate such pathogenic immune responses in animal models. Here, we summarize recent findings from experimental and clinical studies and propose a model for peripheral tolerance induction after BMT. 
8 Citations
Adoptive T Regulatory Cell Therapy for Tolerance Induction

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CD25+ immunoregulatory T-cells of donor origin suppress alloreactivity after BMT.
CD4+CD25+ Immunoregulatory T Cells
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