Immunomodulating therapy with intravenous immunoglobulin in patients with chronic heart failure.

@article{Gullestad2001ImmunomodulatingTW,
  title={Immunomodulating therapy with intravenous immunoglobulin in patients with chronic heart failure.},
  author={Lars Gullestad and Halfdan Aass and Jan Gunnar Fjeld and L Wikeby and Arne Kristian Andreassen and H. Ihlen and S Simonsen and John Kjekshus Kjekshus and Sigurd Nitter-Hauge and Thor Ueland and Eric Lien and Stig Sophus Fr\oland and P{\aa}l Aukrust},
  journal={Circulation},
  year={2001},
  volume={103 2},
  pages={220-5}
}
BACKGROUND Congestive heart failure (CHF) is characterized by enhanced immune activation, and immune-mediated mechanisms may play a pathogenic role in this disorder. Based on the immunomodulatory effects of intravenous immunoglobulin (IVIG), we hypothesized that IVIG could downregulate inflammatory responses in CHF patients and have potential beneficial effects on the left ventricular ejection fraction (LVEF). METHODS AND RESULTS Forty patients with chronic symptomatic CHF and LVEF of <40… CONTINUE READING

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