Immunomodulating Activity of Agaricus brasiliensis KA21 in Mice and in Human Volunteers

@article{Liu2008ImmunomodulatingAO,
  title={Immunomodulating Activity of Agaricus brasiliensis KA21 in Mice and in Human Volunteers},
  author={Ying Liu and Yasushi Fukuwatari and Ko Okumura and Kazuyoshi Takeda and Ken-Ichi Ishibashi and Mai Furukawa and Naohito Ohno and Kazu Mori and Ming Gao and Masuro Motoi},
  journal={Evidence-based Complementary and Alternative Medicine : eCAM},
  year={2008},
  volume={5},
  pages={205 - 219}
}
We performed studies on murine models and human volunteers to examine the immunoenhancing effects of the naturally outdoor-cultivated fruit body of Agaricus brasiliensis KA21 (i.e. Agaricus blazei). Antitumor, leukocyte-enhancing, hepatopathy-alleviating and endotoxin shock-alleviating effects were found in mice. In the human study, percentage body fat, percentage visceral fat, blood cholesterol level and blood glucose level were decreased, and natural killer cell activity was increased. Taken… 
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65 Citations
Background Citations
23
Methods Citations
3
Results Citations
1

65 Citations

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Citation Type

Effects of Agaricus brasiliensis mushroom in Walker-256 tumor-bearing rats.
TLDR
The beneficial effects of A. brasiliensis in tumor treatment, mainly related to cachexia, can be partly related to antioxidant activity and to reduction of weight loss and tumor growth.
Immunostimulation-Mediated Anti-tumor Activity of Bamboo (Sasa senanensis) Leaf Extracts Obtained Under ‘Vigorous’ Condition
TLDR
Activation of macrophages and NK cells by the extracts suggests that the anti-tumor efficacy of the extract is mediated by immunopotentiation, and warrants further translation and clinical investigations.
Agaricus brasiliensis-enriched functional product promotes in mice increase in HDL levels and immunomodulate to Th1 CD4+T subsets. A. brasiliensis functional product and biological benefits.
TLDR
The solid state culture demonstrated to be a very good technique to develop A. brasiliensis mycelium on wheat grains to obtain a protein enriched biocultured material and promoted an increase in the “good cholesterol” plasma concentration and probably expansion of the Th1 CD4+T cells.
Effect of Agaricus brasiliensis-derived cold water extract on Toll-like receptor 2-dependent cytokine production in vitro
TLDR
Cold water extract of the fruit body of A. brasiliensis is prepared and fruit body has some water-soluble TLR ligand complexes, and TLR2 on splenocytes strongly induces IL-6 production, which is suggested to be the receptor that modulates IL- 6 production.
Agaricus brasiliensis-derived β-glucans exert immunoenhancing effects via a dectin-1-dependent pathway.
Immunopathological effects of Agaricus blazei Murill polysaccharides against Schistosoma mansoni infection by Th1 and NK1 cells differentiation.
Agaricus brasiliensis mycelium supplementation in Sarcoma 180tumour-bearing mice reverses the immune response induced by the tumour
TLDR
It is confirmed that dietary supplementation with Agaricus may offer immuno-modulatory activity and protection against tumour growth and downregulated Tumor necrosis factor alpha production in plasma.
Evaluation of Agaricus blazei in vivo for antigenotoxic, anticarcinogenic, phagocytic and immunomodulatory activities.
Effect of mushroom Agaricus blazei on immune response and development of experimental cerebral malaria
TLDR
This study strongly suggests that the administration of A. blazei (aqueous extract or fraction C) was effective in improving the consequences of CM in mice and may provide novel therapeutic strategies.
Ganoderma lucidum and Auricularia polytricha Mushrooms Protect against Carbofuran-Induced Toxicity in Rats
TLDR
The coadministration of mushroom extracts significantly ameliorated the toxic effects of the CF and the GL mushroom extract was more efficacious than that of the AP mushroom, possibly due to the presence of high levels of phenolic compounds and other antioxidants in theGL mushroom.
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