Immunomicrobial pathogenesis of periodontitis: keystones, pathobionts, and host response.

@article{Hajishengallis2014ImmunomicrobialPO,
  title={Immunomicrobial pathogenesis of periodontitis: keystones, pathobionts, and host response.},
  author={George Hajishengallis},
  journal={Trends in immunology},
  year={2014},
  volume={35 1},
  pages={
          3-11
        }
}
Recent studies have uncovered novel mechanisms underlying the breakdown of periodontal host-microbe homeostasis, which can precipitate dysbiosis and periodontitis in susceptible hosts. Dysbiotic microbial communities of keystone pathogens and pathobionts are thought to exhibit synergistic virulence whereby not only can they endure the host response but can also thrive by exploiting tissue-destructive inflammation, which fuels a self-feeding cycle of escalating dysbiosis and inflammatory bone… CONTINUE READING
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References

Publications referenced by this paper.
SHOWING 1-10 OF 93 REFERENCES

A Comparison of Aggregatibacter actinomycetemcomitans (Aa) virulence traits in a rat model for periodontal disease

H Schreiner
  • PLoS ONE 8,
  • 2013

A Comparison of Aggregatibacter actinomycetemcomitans (Aa) virulence traits in a rat model for periodontal disease

H Schreiner
  • PLoS ONE 8,
  • 2013