Immunomicelles: targeted pharmaceutical carriers for poorly soluble drugs.

  title={Immunomicelles: targeted pharmaceutical carriers for poorly soluble drugs.},
  author={Vladimir Torchilin and Anatoly N. Lukyanov and Zhong-gao Gao and Brigitte Papahadjopoulos-Sternberg},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={100 10},
To prepare immunomicelles, new targeted carriers for poorly soluble pharmaceuticals, a procedure has been developed to chemically attach mAbs to reactive groups incorporated into the corona of polymeric micelles made of polyethylene glycol-phosphatidylethanolamine conjugates. Micelle-attached antibodies retained their ability to specifically interact with their antigens. Immunomicelles with attached antitumor mAb 2C5 effectively recognized and bound various cancer cells in vitro and showed an… CONTINUE READING
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