Immunomic, genomic and transcriptomic characterization of CT26 colorectal carcinoma

  title={Immunomic, genomic and transcriptomic characterization of CT26 colorectal carcinoma},
  author={John C. Castle and Martin L{\"o}wer and Sebastian Boegel and Jos de Graaf and Christian Bender and Arbel D. Tadmor and Valesca Boisgu{\'e}rin and Thomas Bukur and Patrick Sorn and Claudia Paret and Mustafa Diken and Sebastian Kreiter and {\"O}zlem T{\"u}reci and Ugur Sahin},
  booktitle={BMC Genomics},
Tumor models are critical for our understanding of cancer and the development of cancer therapeutics. Here, we present an integrated map of the genome, transcriptome and immunome of an epithelial mouse tumor, the CT26 colon carcinoma cell line. We found that Kras is homozygously mutated at p.G12D, Apc and Tp53 are not mutated, and Cdkn2a is homozygously deleted. Proliferation and stem-cell markers, including Top2a, Birc5 (Survivin), Cldn6 and Mki67, are highly expressed while differentiation… CONTINUE READING
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