Immunometabolism: Physiologic role of IL-1β in glucose homeostasis

Abstract

Immunology shows that elevated glucose levels after feeding induce macrophages to secrete IL‐1β, which in turn promotes postprandial insu‐ lin secretion. As insulin enhances macrophage production of IL‐1β, the findings might explain why insulin treatment can result in insulin resist‐ ance. The findings also support the use of therapeutic strategies in type… (More)
DOI: 10.1038/nrendo.2017.11

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