Immunometabolic Pathways in BCG-Induced Trained Immunity

  title={Immunometabolic Pathways in BCG-Induced Trained Immunity},
  author={Rob J W Arts and Agostinho Carvalho and Claudia La Rocca and C. Paredes Palma and Fernando Rodrigues and Ricardo Leal Silvestre and Johanneke Kleinnijenhuis and Ekta Lachmandas and Luis Gafeira Goncalves and Ana Belinha and C Cunha and Marije Oosting and Leo A B Joosten and Giuseppe Matarese and Reinout van Crevel and Mihai G Netea},
  booktitle={Cell reports},
The protective effects of the tuberculosis vaccine Bacillus Calmette-Guerin (BCG) on unrelated infections are thought to be mediated by long-term metabolic changes and chromatin remodeling through histone modifications in innate immune cells such as monocytes, a process termed trained immunity. Here, we show that BCG induction of trained immunity in monocytes is accompanied by a strong increase in glycolysis and, to a lesser extent, glutamine metabolism, both in an in-vitro model and after… CONTINUE READING