Immunomapping of EBA sera to multiple epitopes on collagen VII: further evidence that anchoring fibrils originate and terminate in the lamina densa.

@article{Mcmillan2003ImmunomappingOE,
  title={Immunomapping of EBA sera to multiple epitopes on collagen VII: further evidence that anchoring fibrils originate and terminate in the lamina densa.},
  author={J R Mcmillan and Tetsuri Matsumura and Takashi Hashimoto and Hans Schumann and Leena Bruckner-Tuderman and Hiroshi Shimizu},
  journal={Experimental dermatology},
  year={2003},
  volume={12 3},
  pages={261-7}
}
Epidermolysis bullosa acquisita (EBA) is an autoimmune blistering disease with circulating antibodies to type VII collagen, a major component of anchoring fibrils located at the dermal-epidermal junction. The purpose of this study was to further confirm the ultrastructural organisation of anchoring fibrils and to assess the relationship between the clinical phenotype of EBA and target site of their autoantibodies on anchoring fibrils. We studied the ultrastructural binding site of circulating… CONTINUE READING