Immunology of relapse and remission in multiple sclerosis.

@article{Steinman2014ImmunologyOR,
  title={Immunology of relapse and remission in multiple sclerosis.},
  author={Lawrence Steinman},
  journal={Annual review of immunology},
  year={2014},
  volume={32},
  pages={257-81}
}
Eighty percent of individuals with multiple sclerosis (MS) initially develop a clinical pattern with periodic relapses followed by remissions, called relapsing-remitting MS (RRMS). This period of fluctuating disease may last for a decade or more. Clinical relapses reflect acute inflammation in the central nervous system (CNS), composed of the brain and spinal cord. Often, different anatomic areas in the CNS are involved each time a relapse occurs, resulting in varied clinical manifestations in… CONTINUE READING
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