Immunology of psoriasis.

@article{Lowes2014ImmunologyOP,
  title={Immunology of psoriasis.},
  author={Michelle A. Lowes and Mayte Su{\'a}rez-Fari{\~n}as and James G. Krueger},
  journal={Annual review of immunology},
  year={2014},
  volume={32},
  pages={
          227-55
        }
}
The skin is the front line of defense against insult and injury and contains many epidermal and immune elements that comprise the skin-associated lymphoid tissue (SALT). The reaction of these components to injury allows an effective cutaneous response to restore homeostasis. Psoriasis vulgaris is the best-understood and most accessible human disease that is mediated by T cells and dendritic cells. Inflammatory myeloid dendritic cells release IL-23 and IL-12 to activate IL-17-producing T cells… Expand
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TLDR
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[Pathogenesis of psoriasis].
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The current principles of psoriasis pathogenesis are discussed in the context of modern therapies. Expand
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References

SHOWING 1-10 OF 133 REFERENCES
The psoriatic transcriptome closely resembles that induced by interleukin-1 in cultured keratinocytes: dominance of innate immune responses in psoriasis.
TLDR
The findings suggest that the inflammatory milieu in the epidermal microenvironment in psoriasis is more likely dependent on evolutionarily ancient cytokines such as IL-1, rather than those of the adaptive immune response. Expand
Psoriasis vulgaris: cutaneous lymphoid tissue supports T-cell activation and "Type 1" inflammatory gene expression.
TLDR
An integrated view of disease pathogenesis is presented, taking into account immune biology, broad-scale genomic characterization and the response of psoriasis to immune-targeted therapies. Expand
IL-17A is essential for cell activation and inflammatory gene circuits in subjects with psoriasis.
TLDR
It is suggested that IL-17 is a key "driver" cytokine that activates pathogenic inflammation in subjects with psoriasis and neutralization with ixekizumab might be a successful therapeutic strategy in Psoriasis. Expand
NK Cells and Psoriasis
TLDR
Evidence is emerging to support a role for NK cells in psoriasis, which is a chronic condition of the skin characterised by distinctive scaly plaques with immune cells and cytokines influencing keratinocyte function. Expand
Alefacept reduces infiltrating T cells, activated dendritic cells, and inflammatory genes in psoriasis vulgaris.
TLDR
It is suggested that T cells are the primary target for therapy, but that DCs and a spectrum of type 1 inflammatory genes are coordinately suppressed. Expand
The IL-23/T17 pathogenic axis in psoriasis is amplified by keratinocyte responses.
TLDR
The discovery of these genetic mutations in familial and pustular psoriasis suggests new links between cytokine-induced gene products and IL-1 family members from keratinocytes, which may regulate features of the disease, including epidermal hyperplasia and neutrophil infiltrating responses. Expand
A single intradermal injection of IFN-γ induces an inflammatory state in both non-lesional psoriatic and healthy skin
TLDR
IFN-γ, which is significantly elevated in non-lesional skin compared to healthy skin, appears to be a key pathogenic cytokine that can induce many features of the inflammatory cascade of psoriasis. Expand
The Effects of IL-20 Subfamily Cytokines on Reconstituted Human Epidermis Suggest Potential Roles in Cutaneous Innate Defense and Pathogenic Adaptive Immunity in Psoriasis
TLDR
It is shown that primary human keratinocytes express receptors for these cytokines and that IL-20 subfamily cytokines induce acanthosis in reconstituted human epidermis (RHE) in a dose-dependent manner. Expand
Th17 cytokines stimulate CCL20 expression in keratinocytes in vitro and in vivo: implications for psoriasis pathogenesis.
TLDR
It is shown that Th17 cytokines stimulate CCL20 production in vitro and in vivo, and thus provide a potential explanation of how CCR6-positive Th17 cells maintain their continual presence in psoriasis through a positive chemotactic feedback loop. Expand
Characterization of dermal dendritic cells in psoriasis. Autostimulation of T lymphocytes and induction of Th1 type cytokines.
TLDR
In the absence of exogenous mitogens, PP skin-derived DDCs were much more effective stimulators of spontaneous T cell proliferation compared with either psoriatic blood-derived or NN skin- derived dendritic cells. Expand
...
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2
3
4
5
...