Immunology of neuromyelitis optica during pregnancy

@inproceedings{Davoudi2016ImmunologyON,
  title={Immunology of neuromyelitis optica during pregnancy},
  author={Vahid Davoudi and Kiandokht Keyhanian and Riley M Bove and Tanuja Chitnis},
  booktitle={Neurology(R) neuroimmunology & neuroinflammation},
  year={2016}
}
Anti-aquaporin-4 (AQP4) autoantibody plays a key role in the pathogenesis of neuromyelitis optica (NMO). Studies have shown increased relapse rates in patients with NMO during pregnancy and postpartum. High estrogen levels during pregnancy can increase activation-induced cytidine deaminase expression, which is responsible for immunoglobulin production. Additionally, sex hormones may influence antibody glycosylation, with effects on antibody function. Estrogen decreases apoptosis of self… CONTINUE READING
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