Immunology of inflammatory bowel disease and molecular targets for biologics.

  title={Immunology of inflammatory bowel disease and molecular targets for biologics.},
  author={Maneesh Dave and Konstantinos Antonios Papadakis and William A. Faubion},
  journal={Gastroenterology clinics of North America},
  volume={43 3},
Inflammatory bowel disease (IBD) is an immune-mediated disease and involves a complex interplay of host genetics and environmental influences. Recent advances in the field, including data from genome-wide association studies and microbiome analysis, have started to unravel the complex interaction between host genetics and environmental influences in the pathogenesis of IBD. A drawback of current clinical trials is inadequate or lack of immune phenotyping of patients. However, recent advances in… CONTINUE READING
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