Immunology of TLR-independent vaccine adjuvants.

  title={Immunology of TLR-independent vaccine adjuvants.},
  author={Ennio de Gregorio and Ugo D'Oro and Andreas Wack},
  journal={Current opinion in immunology},
  volume={21 3},
Vaccine adjuvants target the innate immune system to enhance the immunogenicity of coadministered antigens. Dendritic cells (DCs) are responsible for antigen uptake and presentation to naïve T cells and represent a key target of adjuvant activity. Adjuvants derived from microbial components, such as Toll-like receptor (TLR) agonists, elicit innate immune receptors expressed by DCs. By contrast, particulate adjuvants, like mineral salts, oil-in-water emulsions, and microparticles, do not… CONTINUE READING


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